@article { author = {Kamal, Mohamed and El-Gerbed, Mohamed and Talaat, Aml and Abdul-aziz, Karoline and Shalaby, Ahmed and Khedr, Rasha and Salem, Mohamed}, title = {Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients}, journal = {International Journal of Cancer and Biomedical Research}, volume = {5}, number = {4}, pages = {135-145}, year = {2021}, publisher = {The Egyptian Association for Cancer Research (EACR)}, issn = {2682-261X}, eissn = {2682-2628}, doi = {10.21608/jcbr.2021.63387.1176}, abstract = {Background: The biology of breast cancer was shown to vary in different ethnic populations. Fibronectin (FN) and laminin (LN) are adhesive glycoproteins present in the extracellular matrix (ECM) and have been shown to associate with prognosis of breast cancer patients. However, their prognostic values have not been fully studied. Aim: We aim to study the prognostic values of FN and LN in breast cancer patients. Materials and Methods: Here, we used immunohistochemical (IHC) staining to investigate the expression patterns of FN and LN in 77 breast cancer patients and to evaluate their prognostic values. Results: High expression levels of FN and LN were detected in 72.7% and 67.5% of cases, respectively. High FN expression was associated with longer overall survival (OS) and disease-free survival (DFS). Moreover, multivariate analysis showed that FN is an independent prognostic factor for OS and DFS. No significant associations detected between LN expression and clinicopathological parameters or survival data. Conclusion: Our results suggest that FN and LN biomarkers biologically function differently in breast cancer.}, keywords = {reast cancer,Fibronectin,Immunohistochemistry,Laminin,prognostic marker}, url = {https://jcbr.journals.ekb.eg/article_197887.html}, eprint = {https://jcbr.journals.ekb.eg/article_197887_41a4f9f903041a31837403e6c994cb0c.pdf} }