• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
International Journal of Cancer and Biomedical Research
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 6 (2022)
Volume Volume 5 (2021)
Volume Volume 4 (2020)
Issue Issue 3
Issue Issue 2
Issue Special Issue
Issue Issue 1
Volume Volume 3 (2019)
Volume Volume 2 (2018)
Volume Volume 1 (2017)
Seifeldein, G., Elsaba, T., Gabr, A., Mohamed, D., Elmorshidy, S., Atta, H. (2020). The diagnostic efficacy of tailored multiparametric breast MRI in indeterminate mammographic lesions: A single tertiary oncology center. International Journal of Cancer and Biomedical Research, 4(3), 217-228. doi: 10.21608/jcbr.2020.36193.1057
Gehan Seifeldein; Tarek M. Elsaba; Adel Gabr; Dalia O. Mohamed; Summer Elmorshidy; Haisam Atta. "The diagnostic efficacy of tailored multiparametric breast MRI in indeterminate mammographic lesions: A single tertiary oncology center". International Journal of Cancer and Biomedical Research, 4, 3, 2020, 217-228. doi: 10.21608/jcbr.2020.36193.1057
Seifeldein, G., Elsaba, T., Gabr, A., Mohamed, D., Elmorshidy, S., Atta, H. (2020). 'The diagnostic efficacy of tailored multiparametric breast MRI in indeterminate mammographic lesions: A single tertiary oncology center', International Journal of Cancer and Biomedical Research, 4(3), pp. 217-228. doi: 10.21608/jcbr.2020.36193.1057
Seifeldein, G., Elsaba, T., Gabr, A., Mohamed, D., Elmorshidy, S., Atta, H. The diagnostic efficacy of tailored multiparametric breast MRI in indeterminate mammographic lesions: A single tertiary oncology center. International Journal of Cancer and Biomedical Research, 2020; 4(3): 217-228. doi: 10.21608/jcbr.2020.36193.1057

The diagnostic efficacy of tailored multiparametric breast MRI in indeterminate mammographic lesions: A single tertiary oncology center

Article 8, Volume 4, Issue 3, December 2020, Page 217-228  XML PDF (11.41 MB)
Document Type: Original Article
DOI: 10.21608/jcbr.2020.36193.1057
Authors
Gehan Seifeldeinorcid 1; Tarek M. Elsaba2; Adel Gabr3; Dalia O. Mohamed4; Summer Elmorshidy5; Haisam Atta email orcid 6
1Diagnostic and Interventional Radiology Department, Assiut University, Egypt.
2Pathology Department, South Egypt Cancer Institute, Assiut University, Egypt
3Medical Oncology Department, South Egypt Cancer Institute, Assiut
4Radiotherapy Department, South Egypt Cancer Institute, Assiut University, Egypt
5Clinical Oncology Department, Faculty of Medicine, Assiut University,Egypt
6South Egypt Cancer Institute-Assiut University, Assiut University, Egypt
Abstract
Aim: Assessing the diagnostic role of multiparametric MRI (mpMRI) in indeterminate mammographic breast lesions and postulated a diagnostic model for MRI interpretation integrating the morphological, and functional parameters.
Material and Methods: Two hundred forty patients included in a self-control retrospective study in a tertiary center. All patients examined with 1.5T MR unit using multiparametric studies including morphological analysis followed by functional evaluation via MR diffusion (MR-DWI), spectroscopy(MRS), and kinetic enhanced curves (DCE-MRI). Diagnostic performance of each parameter was evaluated alone and in combination. The histopathological results were the standard of reference. Results: Combined mpMRI parameters possess a moderate agreement (κ=0.435) with 23.5% false discovery rate (FDR) and an overall accuracy of 78%.On the other hand, combined mpMRI data after omitting MRS data show almost perfect agreement (κ=0.923)with histopathological data and recorded 100% specificity, 90% specificity, 5% FDR and zero% for both false omission rate (FOR) and false-negative rate (FNR). The Quantitative analysis of DWI with ADC map shows a significant statistical value for mean ADC (m-ADC) value and relative ADC (r-ADC) value. The former has cutoff value 1.1x10-3 mm2/sec with higher specificity 97.5% while r-ADC has cutoff value 0.42x10-3 mm2/sec with quite lower specificity 85%. Perfect agreement in the interpretation of DCE-MRI curves, MR-DWI, and MRS with κ =0.92,0.9 and 0.84 respectively.  Conclusion: Tailored combined multiparametric MRI is a potent diagnostic tool in the characterization of indeterminate mammographic breast lesions.
Keywords
BI-RADS; Diffusion-weighted imaging; Magnetic resonance spectroscopy; MRI; Multiparametric
Main Subjects
Anti-cancer Immunotherapy; Cellular and molecular targeting; Computational based cancer therapy; Photo-dynamic therapy
Statistics
Article View: 213
PDF Download: 197
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.