Utilization of Nitrogenous Precursors for Synthesis of Either Fused or Binary Heterocyclic Systems: Their Bioassay as Antimicrobial and Antitumor: Thesis Abstract

Elbana, Ghada Gamal; Zoorob, Hanafi; Shaaban, Saad; Hamama, Wafaa

doi:10.21608/jcbr.2021.60293.1148

Utilization of Nitrogenous Precursors for Synthesis of Either Fused or Binary Heterocyclic Systems: Their Bioassay as Antimicrobial and Antitumor: Thesis Abstract

Document Type : Essay Abstract

Authors

¹ Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, Egypt

² Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.

10.21608/jcbr.2021.60293.1148

Abstract

Thesis Abstract
Triazines represent a promising scaffold for cancer treatment due to their similarity to the biologically active purine and pyrimidine systems. Besides, triazines and annulated compounds exist in the skeleton of numerous natural and synthetic chemotherapeutic agents such as Azanucleosides (6-azacytosine and 6-azauracil). Also, triazine derivatives proved to display antiviral, anti-inflammatory, antimicrobial and antifungal activities. Moreover, it was found that triazine derivatives display significant wide spectrum anticancer activities against lymphoblastic lung adenocarcinoma A549, leukemia CEM and myeloid leukemia K562 cancer cell lines. In this regard, newly series of triazine-based thiadiazol, thiadiazine, thiadiazepine, pyrazole tetrazepino[b]indol-one, triazolotriazine, tetrazolotriazine, triazinotetrazine, and triazinotetrazepinoindole moieties were synthesized, spectrally discussed and mechanistically discussed. On the other hand, the synthesized compounds were evaluated against different types of biological bioassays (Antitumor, Antioxidant and Antimicrobial). Also, compounds 33c and 37 were evaluated against three human cancer cell lines (HepG‐2, HCT‐116, and MCF‐7) for their in-vitro anticancer activities. The results declared that all compounds had a potent anticancer activity with IC50 values ranging between 10.8 and 23.4 μM.

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