Molecular and immunological investigation of neuroinflammation induced by mycotoxines: Thesis Abstract

Ismail, Nadia Fouad; El-Saied, Mohamad; El Demellawy, Maha; Ghareeb, Doaa; El Sohaimy, Sobhy

doi:10.21608/jcbr.2021.61334.1161

Molecular and immunological investigation of neuroinflammation induced by mycotoxines: Thesis Abstract

Document Type : Essay Abstract

Authors

¹ Lecturer, Medical laboratory technology Department, Faculty of Allied Medical Sciences, Pharos University in Alexandria, Alexandria. Egypt.

² Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria Egypt.

³ Medical Biotechnology Department (MBD), Genetic Engineering and Biotechnology Research Institute (GEBRI), Pharmaceutical & Fermentation Industries Development Center (PFIDC),City for Scientific Research and Technology Applications (SRTA-City)

⁴ Prof. of Biochemistry, Faculty of Science, Alexandria University, Egypt City for Scientific Research and Technology Applications (SRTA-City)

⁵ Department of Food Technology, City for Scientific Research & Technology Applications, New Borg El Arab, Alexandria, Egypt

10.21608/jcbr.2021.61334.1161

Abstract

Neuroinflammation represents the coordinated cellular response to tissue damage. Mycotoxins are low-molecular-weight natural products produced as secondary metabolites by filamentous fungi. The toxic effect of mycotoxins on animal and human health is referred to as mycotoxicosis, Fusarium species are the main pathogenic fungi causing maize ear and kernel rot worldwide, mainly produce fumonisin B (FB) that contaminate grains and grain products.
In this study, fungi were isolated from corn seeds and ethanolic natural product crude extracts were used as antifungal compounds. Antifungal effects of three extracts were assessed in vitro on toxin production and different toxin concentrations (in vitro study). A newly identified sequence was registered to our study group and was given a new accession number by GenBank. The inhibitoriest effect for the production of fumonisin B1 was for Cinnamuom zeilanicum followed by Berberise vulgaris and finally Calluna vulgaris.
Gene expression by Real time PCR the fold change calculated values for the assessment of IL-1β,COX II, iNOS and TNF-α gene expressions showed at P

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