Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

Document Type : Original Article

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Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

Abstract

Background:Rosemary (ROLE) and costus (SLRE) have been established to show antioxidant effects. Aim: This study aimed to evaluate the ameliorating effects of ROLE and SLRE to the side-effects induced by cisplatin (CIS) in tumor-bearing mice. Materials and Methods: Extracts of ROLE and SLRE were examined for their phytochemical activities. To ecaluate their anti-tumor effects, mice were inoculated intraperitoneally (i.p.) with 2.5x105 Ehrlich ascites carcinoma (EAC) and then treated i.p. with CIS at days 3-7 and with ROLE (dose) or SLRE (dose) at days 3-14. Mice were sacrificed on day 14 for CBC and T-cell analyses. Results: Phytochemical analysis revealed that both ROLE and SLRE showed similar antioxidant activities. Treatment of EAC-bearing mice with CIS induced antitumor efficacy of about 90%.  Treatment with CIS in combination of ROLE or SLRE  did not further enhance the the antitumor activity of CIS. However, co-administration of ROLE or SLRE with CIS increased significantly the antitumor efficacy of CIS. Flow cytometric analysis showed that the numbers of CD4+ and CD8+ T cells were decreased in EAC bearing mice after treatment with CIS. Treatment with both ROLE and SLRE improved the number of these cells. Conclusion: Combinatorial treatment with rosemary and costus

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Egyptian Journal of Cancer and Biomedical Research
Volume 5, Issue 4
December 2021
Pages 85-98

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