Dosimetric Comparison between Simultaneous Integrated Boost Dynamic Conformal Arc Therapy and Whole Brain Radiation Therapy Techniques in Treatment of Patients with Multiple Brain Metastases

ElDrieny, Ahmed M; Ahmed, Ahmed Adel; Mahmoud, Nayera; Darwish, Azza

doi:10.21608/jcbr.2024.298063.1358

Dosimetric Comparison between Simultaneous Integrated Boost Dynamic Conformal Arc Therapy and Whole Brain Radiation Therapy Techniques in Treatment of Patients with Multiple Brain Metastases

Document Type : Original Article

Authors

¹ pharos university, Alexandria, Egypt

² Ayadi Almostakbal Oncology Hospital, Alexandria, Egypt. -Alexandria Clinical Oncology Department, Alexandria University, Alexandria, Egypt.

³ Alexandria Clinical Oncology Department, Alexandria University, Alexandria, Egypt.

⁴ Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

10.21608/jcbr.2024.298063.1358

Abstract

Background: Whole Our study aims to compare between the dosimetric results and treatment delivery efficiency of Whole Brain Radiation Therapy (WBRT) versus Simultaneous Integrated Boost Dynamic Conformal Arc Therapy (DCAT) planning techniques – to explore which is the better technique in brain metastases treatment. Methods: WBRT and DCAT plans were created for 20 patients treated for brain metastases using the Eclipse™ treatment planning system (Varian Medical Systems). The WBRT plan was planned to deliver 20 Gy to the planning target volumes (PTVs) in 5 fractions, while DCAT plan was planned to deliver the PTVs 25 Gy in 5 fractions. Target coverage and organs at risk (OARs) sparing were compared in both techniques. The number of delivered monitor units (MUs) and the treatment time were also used to assess the efficiency of each plan. Results: The study results revealed better Planning Target Volumes (PTVs) dose coverage in the DCAT plan compared to WBRT, while maintaining significantly lower OAR doses. Conclusion: DCAT plans deliver higher doses to brain metastases and minimal doses to OARs. Therefore, dose escalated DCAT for small and large lesions allow higher radiotherapy doses to be delivered to small and larger lesions, all while maintaining safe doses to the surrounding OARs.

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