Document Type : Original Article
Authors
1
Department of oncology, Beni-Suef University, Beni-Suef, Egypt. Depaetment of pediatric oncology, Children Cancer Hospital Egypt
2
Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt Department of Clinical Oncology, Menufiya University, Shebeen, Egypt
3
Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt Department of Pediatric Oncology, National Cancer Institute/ Cairo University, Cairo, Egypt
4
Department of Pathology/ National Cancer Institute/ Cairo University, Cairo, Egypt Department of Pathology, Children Cancer Hospital Egypt, Cairo, Egypt
5
Department of Nuclear Medicine, Children Cancer Hospital Egypt, Cairo, Egypt Department of Nuclear Medicine, National Cancer Institute/ Cairo University, Cairo, Egypt
6
Department of Clinical Research, Children Cancer Hospital Egypt, Cairo, Egypt
7
Department of radiodiagnosis/ National Cancer Institute/ Cairo University, Cairo, Egypt Department of Radiodiagnosis, Children Cancer Hospital Egypt, Cairo, Egypt
8
Department of Radiotherapy, National Cancer Institute/ Cairo University, Cairo, Egypt Department of Radiotherapy, Children Cancer Hospital Egypt, Cairo, Egypt
Abstract
Background: Ionizing radiation is a breast cancer risk factor. This retrospective study aims to compare the outcome of young adolescent females diagnosed and treated with classic Hodgkin lymphoma who received chemotherapy while omitting radiotherapy for fear of the increased risk of breast cancer and those who received chemotherapy followed by radiotherapy in an attempt to explore the impact of radiotherapy on the outcome and to record the late side effects of radiotherapy as well as the incidence of breast cancer among these patients.
About 166 young adolescent females between 12 and 18 years old were diagnosed and treated with classic Hodgkin lymphoma in the Children’s Cancer Hospital Egypt from July 2007 till the end of 2018, the no radiotherapy (RT) group (72 patients) received chemotherapy while omitting radiotherapy, the RT group (94 patients) received chemotherapy and radiotherapy, with 5years OS 93%, 87% respectively, and with 5years EFS 74%, 85% respectively, with P-value 0.062. The initial stage and response to treatment using interim PET CT scans post-second cycle chemotherapy were documented. The outcomes were nearly identical in the no RT and RT groups. In conclusion, omitting radiation therapy did not affect the 5-year EFS; nevertheless, the existence of positive B symptoms, an advanced stage initially, or a poor response to treatment all impacted the 5-year EFS.
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