Protective activities of Nigella sativa and its active gradient thymoquinone on the carcinogenic effects of N-butyl-N-(4-hydroxybutyl)nitrosamine on Wistar rats
1
Zoology Department, Faculty of Science, Tanta University, Egypt
2
Tanta University, Faculty of Science, Department of Zoology
Abstract
Background: Carcinogens become a serious environmental challenge. Aim: The main aim of this study was to assess the alterations in some biochemical parameters in male Wistar rats after. Materials and Methods: Experimental groups were administered with 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) followed by 5% Sodium ascorbate (Na-As), then they were post-treated with Nigella sativa (N. sativa) by an inter-gastric luminal gavage or with thymoquinone (TQ) by inter-peritoneal injections. Blood samples were collected after a 32 weeks’ experiment. Results: TQ seemed to have a powerful inhibitory effect on total cholesterol and triacylglycerol levels. While levels of A/G ratio, ALT and AST were highly decreased by both of N. sativa and TQ. Conclusion: These findings may rely on the lipid-modifying and hepatoprotective effects of N.sativa crude oil and its main constituent TQ on mammals. Thus, further investigations are required.
Salim, E., & Khalifa, A. (2018). Protective activities of Nigella sativa and its active gradient thymoquinone on the carcinogenic effects of N-butyl-N-(4-hydroxybutyl)nitrosamine on Wistar rats. International Journal of Cancer and Biomedical Research, 2(2), 14-20.
MLA
Elsayed I. Salim; Areeg Khalifa. "Protective activities of Nigella sativa and its active gradient thymoquinone on the carcinogenic effects of N-butyl-N-(4-hydroxybutyl)nitrosamine on Wistar rats". International Journal of Cancer and Biomedical Research, 2, 2, 2018, 14-20.
HARVARD
Salim, E., Khalifa, A. (2018). 'Protective activities of Nigella sativa and its active gradient thymoquinone on the carcinogenic effects of N-butyl-N-(4-hydroxybutyl)nitrosamine on Wistar rats', International Journal of Cancer and Biomedical Research, 2(2), pp. 14-20.
VANCOUVER
Salim, E., Khalifa, A. Protective activities of Nigella sativa and its active gradient thymoquinone on the carcinogenic effects of N-butyl-N-(4-hydroxybutyl)nitrosamine on Wistar rats. International Journal of Cancer and Biomedical Research, 2018; 2(2): 14-20.
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