Effect of Moringa oleifera on antioxidant enzymes and oxidative stress induced by aluminium exposure in male albino rat testes

This study summarizes the effect of Moringa oleifera leaves extract on oxidative stress-induced from exposure to aluminium (aluminium chloride, AlCl₃) on testes of male albino rats. Fifteen male albino rats (250.0±10.0) g were divided into five groups, each group of 10 rats. Group one received sterile water orally as a control, group two received AlCl₃ (50mg/kg/day), group three received M. oleifera (300mg/kg/day), group four received AlCl3 (50mg/kg/day) for four weeks then M. oleifera (300mg/kg/day) for four weeks and last group five received AlCl₃ and M. oleifera for eight weeks. The results showed significant changes in testes parameters where there was a decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione -s-transferase (GST) and glutathione peroxidase (GPx) associated with increase in the activity of xanthine oxidase (XO) and malondialdehyde (MDA) levels in aluminium treated groups. Also, there was an improvement in the activity of the enzymes (SOD, CAT, GST, and GPx) associated with a decrease in the activity of XO and MDA in groups received M. oleifera. These results proved that M. oleifera has an ameliorative effect on the activities of antioxidant enzymes and oxidative stress-induced from exposure to aluminium in male albino rats.