EMMPIRRIN (CD147) and matrix metalloproteinase-9 (MMP9) immunohistochemical expression in breast carcinoma: Relationship with clinicopathological paremeters
Background: Breast cancer is one of the leading causes of cancer mortality in women worldwide. Despite significant advances in cancer treatment, mortality results from local invasion and/or distant metastasis. Aim: To evaluate EMMPIRIN (CD147) and matrix metalloproteinase-9 (MMP9) immunohistochemical expressions significance in invasive ductal breast carcinoma cases in relation to other clinicopathological parameters. Materials and Methods: The study included 50 specimens of surgically resected breast carcinomas in which the expression of CD147and MMP9 was assessed. The results were compared statistically with chi-square (χ2) and Fisher exact test. Results: CD174 overexpression showed significant association with poorly differentiated tumors, staging, presence of nodal metastasis and high Ki67 expression. There was a significant correlation between high MMP9 expression and pathological variables as tumor staging, positive nodal metastasis, low ER expression and high HER2 expression. Conclusion: The results of this study suggest that high expressions of EMMPRIN and MMP9 correlate to poor prognostic parameters. Targeted therapy might improve the prognosis of patients with CD147 and MMP-9 overexpression.
Mowafy, S., & Amer, B. (2020). EMMPIRRIN (CD147) and matrix metalloproteinase-9 (MMP9) immunohistochemical expression in breast carcinoma: Relationship with clinicopathological paremeters. Egyptian Journal of Cancer and Biomedical Research, 4(1), 35-42. doi: 10.21608/jcbr.2020.26206.1015
MLA
Shorouk Mowafy; Basma Amer. "EMMPIRRIN (CD147) and matrix metalloproteinase-9 (MMP9) immunohistochemical expression in breast carcinoma: Relationship with clinicopathological paremeters", Egyptian Journal of Cancer and Biomedical Research, 4, 1, 2020, 35-42. doi: 10.21608/jcbr.2020.26206.1015
HARVARD
Mowafy, S., Amer, B. (2020). 'EMMPIRRIN (CD147) and matrix metalloproteinase-9 (MMP9) immunohistochemical expression in breast carcinoma: Relationship with clinicopathological paremeters', Egyptian Journal of Cancer and Biomedical Research, 4(1), pp. 35-42. doi: 10.21608/jcbr.2020.26206.1015
VANCOUVER
Mowafy, S., Amer, B. EMMPIRRIN (CD147) and matrix metalloproteinase-9 (MMP9) immunohistochemical expression in breast carcinoma: Relationship with clinicopathological paremeters. Egyptian Journal of Cancer and Biomedical Research, 2020; 4(1): 35-42. doi: 10.21608/jcbr.2020.26206.1015