Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients

Kamal, Mohamed; El-Gerbed, Mohamed; Talaat, Aml; Abdul-aziz, Karoline; Shalaby, Ahmed; Khedr, Rasha; Salem, Mohamed

doi:10.21608/jcbr.2021.63387.1176

Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients

Document Type : Original Article

Authors

¹ Stem Cell and Regenerative Medicine Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California (USC) Room 3514, Norris Research Tower, 1441 Eastlake Ave, Los Angeles, UAS.

² Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt.

³ Department of Oncologic Pathology, Damanhour National Medical Institute, Damanhour, El-Behera, Egypt.   Pathology Department, Faculty of Medicine, Nagasaki University, Japan.  

⁴  Department of clinical Oncology, Faculty of Medicine, Tanta University, Tanta, Egypt. 

⁵ Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

10.21608/jcbr.2021.63387.1176

Abstract

Background: The biology of breast cancer was shown to vary in different ethnic populations. Fibronectin (FN) and laminin (LN) are adhesive glycoproteins present in the extracellular matrix (ECM) and have been shown to associate with prognosis of breast cancer patients. However, their prognostic values have not been fully studied. Aim: We aim to study the prognostic values of FN and LN in breast cancer patients. Materials and Methods: Here, we used immunohistochemical (IHC) staining to investigate the expression patterns of FN and LN in 77 breast cancer patients and to evaluate their prognostic values. Results: High expression levels of FN and LN were detected in 72.7% and 67.5% of cases, respectively. High FN expression was associated with longer overall survival (OS) and disease-free survival (DFS). Moreover, multivariate analysis showed that FN is an independent prognostic factor for OS and DFS. No significant associations detected between LN expression and clinicopathological parameters or survival data. Conclusion: Our results suggest that FN and LN biomarkers biologically function differently in breast cancer.

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